Martyn, Amanda

Assistant Professor of Biology
School of Arts and Sciences
PhD Molecular & Cellular Biology, University of Guelph
MSc Plant Biology, University of Guelph
BSc Honors Molecular Biology & Genetics, University of Guelph

About

A Canadian native, Dr. Amanda Martyn grew up in Ontario, just north of Toronto. She has a Ph.D. from the University of Guelph, specializing in the stress response and molecular neuropsychology. Dr. Martyn additionally completed a post-­doctoral fellowship at the Robarts Research Institute at Western University in London, Ontario, Canada, studying Alzheimer’s disease, and, after relocating to North Carolina, a post-­doctoral fellowship at Duke University, studying Post-Traumatic Stress Disorder (PTSD). Her research contributions have been published in peer-reviewed scientific journals.

Between graduate degrees, Dr. Martyn spent several years as a coordinator for multiple molecular biology courses at the University of Guelph, teaching upcoming scientists general molecular biology theory and technique in both a classroom and laboratory setting.

In 2013, Dr. Martyn joined the NC School of Science and Mathematics as an Instructor of Biology, teaching courses Molecular & Classical Genetics, Epidemiology, Global Public Health and Forensic Science in the online and open enrollment programs. She has earned the 2019 North Carolina Association for Biomedical Research (NCABR) Distinguished Teacher in STEM Education and in March 2020 was awarded a Burroughs Wellcome Fund Promoting Innovation in Science and Mathematics (PRISM) Grant.

Dr. Martyn is also an active member with 100Kin10, an organization whose mission is to identify and improve on the grand challenges of STEM education nationwide.

When not inspiring students, Dr. Martyn is spending time with her family, teaching horseback riding in the equestrian discipline of dressage, training her Lusitano mare named Luna, or cheering on the Carolina Panthers. #keeppounding

Publications

Martyn AC, Toth K, Schmalzigaug R, Hedrick NG, Rodriguiz RM, Yasuda R, Wetsel WC, Premont RT. (2018). GIT1 regulates synaptic structural plasticity underlying learning. PLOS One. 13(3):e0194350. PMID: 29554125.

Ostapchenko VG, Chen M, Guzman MS, Xie YF, Lavine N, Fan J, Beraldo FH, Martyn AC, Belrose JC, Mori Y, MacDonald JF, Prado VF, Prado MA, Jackson MF. (2015). The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to -Amyloid Oligomer-Related Neurotoxicity and Memory Impairment. J. Neuroscience. 35(45): 15157-15169. PMID: 26558786.

Beraldo FH, Thomas A, Kolisnyk B, Hirata PH, De Jaeger X, Martyn AC, Fan J, Goncalves DF, Cowan MF, Masood T, Martins VR, Gros R, Prado VF, Prado MA. (2015). Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1). Dis Model Mech. 8(11):1457-66. doi: 10.1242/dmm.022525.

Bedore J, Martyn AC, Li AKC, Dolinar EA, McDonald IS, Coupland SG, Prado VF, Prado MA, Hill KA. (2015). Whole-Retina Reduced Electrophysiological Activity in Mice Bearing Retina-Specific Deletion of Vesicular Acetylcholine Transporter. PLOS ONE. 10(7): e0133989. PMID: 26226617.

Denboer LM, Iyer A, McCluggage AR, Li Y, Martyn AC, Lu R. (2013).  JAB1/CSN5 inhibits the activity of Luman/CREB3 by promoting its degradation.  Biochem Biophys Acta. 1829(9):921-929.  PMID: 23583719.

Yang Y, Jin Y, Martyn AC, Pengfe, L, Song Y, Chen F, Hu L, Cui C, Li X, Li Q, Lu R, Want A. (2013). Expression pattern implicates a potential role for LRF in the process of implantation in uteri and development of preimplantation embryos in mice. J. Reprod. Dev. 2013 Feb 12. [Epub ahead of print]. PMID: 23400243.

Martyn AC, Choleris E, Gillis DJ, Armstrong JN, Turner PV, Liang G, Cai K, Lu R. (2012). Luman/CREB3 recruitment factor (LRF) deficiency affects the hypothalamic-pituitary-adrenal axis and prolactin-mediated maternal responsiveness. Mol. Cell. Biol. 32(24):5140-5150. PMID: 23071095.

Martyn AC, De Jaeger X, Magalhaes AC, Kesarwani R, Goncalves DF, Raulic S, Guzman MS, Jackson MF, Izquierdo I, MacDonald JF, Prado MAM, Prado VF. (2012). Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiation. PNAS 109(43): 17651-17656. PMID: 23045697.

Zhang Y, Jin Y, Williams TA, Burtenshaw SM, Martyn AC, Lu R. (2010). Amino acid deprivation induces CREBZF/Zhangfei expression via an AARE-like element in the promoter. BBRC 391: 1352-1357. PMID: 20026304.

Liang G, Audas TE, Li Y, Cockram GP, Dean D, Martyn AC, Kokame K, Lu R. (2006). Luman/CREB3 induces transcription of the endoplasmic reticulum stress response protein, Herp, through an ERSE-II element. Mol. Cell. Biol. 26(21): 7999-8010. PMID: 16940180.

Reid AJ, Rogers AC, Greenwood JS. (2001). Rapid plastic embedding is compatible with colorimetric detection following whole mount in situ hybridization in plant specimens. Biotechnic & Histochemistry 76(1): 3-10. PMID: 11440300.

Martyn, Amanda